You can treat them like characters, like in a MOBA to make it easier to familiarize yourself. These are essentially machine space ninjas each with their own unique set of skills.
To add to that, there are also numerous warframes to choose from. It features systems on top of systems that you cannot skip since you're essentially handicapping yourself if you do so. Part of the reason why is due to Warframe's steep learning curve. Surprisingly, it doesn't seem to get the spotlight it very much deserves. Warframe is one of the best, if not THE BEST, free-to-play online game out there.